Loratadine for Improvement of Bone Pain in Patients With Chronic Granulocyte-Colony Stimulating Factor (G-CSF) Use

Stopped early · Phase 2 · Has a placebo group

Conditions studied: Bone Pain

In brief

G-CSF causes a release of histamine that may be a cause of chronic bone pain. Loratadine targets histamine, and so may be effective in reducing bone pain.The researchers plan to prospectively assess the effectiveness of loratadine for chronic bone pain in patients with chronic G-CSF use.

Key facts

Study ID

NCT03883386

Run by

University of Michigan

People needed

3

Starts

2019-06-24

Expected to finish

2019-10-18

Last updated by the study team

2020-10-22

Who can join

Age: 12 and older, up to 99. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of neutropenia
• Granulocyte-colony stimulating factor (G-CSF) use for at least 3 months at least 4 times per month
• Mean bone pain of at least a 2/10 as assessed by questions 3-6 of the Brief Pain Inventory (BPI)

You may not qualify if…

• Other sources of chronic pain
• Previously tried loratadine for 7 consecutive days or more for bone pain
• Allergy to loratadine
• Chronic daily usage of antihistamine without an acceptable alternative non-antihistamine medication

Where it is running

• The University of Michigan — Ann Arbor, Michigan, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.