The Influence of Multi-domain Cognitive Training on Large-scale Structural and Functional Brain Networks in MCI

Completed · Not applicable

Conditions studied: Mild Cognitive Impairment

In brief

The purpose of this study is to integrate advanced computational techniques and multimodal neuroimaging methods to examine the potential effects of long-term, multi-domain, online, computerized cognitive training on large-scale structural and functional brain networks in older adults with mild cognitive impairment (MCI).

Key facts

Study ID

NCT03883308

Run by

Stanford University

People needed

60

Starts

2017-10-30

Expected to finish

2020-12-01

Last updated by the study team

2021-05-05

Who can join

Age: 65 and older, up to 85. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Cognitive concern by subject, informant or physician
• Impairment in memory domain (delayed recall of one paragraph from Logical Memory II subscale from Wechsler memory Scale - Revised with cutoff scores of <=8, <=4 and <=2 for 16, 8-15 and 0-7 years of education)
• Essentially normal functional activities
• Mini-Mental State Examination (MMSE) scores >=24
• Stability of permitted medications (e.g. cholinesterase inhibitors, hypertension medication, etc.) for at least two months.

You may not qualify if…

• Any significant neurological condition including probable dementia, Parkinson's disease, Huntington's disease, multiple sclerosis, and brain tumor, among others.
• Presence of Axis I disorder
• Current use of psychoactive medications except for the permitted medications.
• Claustrophobia
• MRI contraindication
• Any significant systemic or unstable medical condition which could lead to difficulty complying with the protocol.

Where it is running

• Stanford University School of Medicine — Stanford, California, United States

Full record on ClinicalTrials.gov

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