PRISM Intervention Study
Running, not enrolling · Not applicable
Conditions studied: Autism Spectrum Disorder
In brief
This research study, Personalized, Responsive Intervention Sequences for Minimally Verbal Children with Autism (PRISM), is designed to maximize language outcomes for limited-language preschoolers, thereby lowering the risk of being classified as "minimally verbal" at age 6, by empirically developing a two-stage, 20-week adaptive intervention approach in a real world community settings. If found efficacious, the adaptive intervention design will capitalize on the heterogeneity and evolving status of children with ASD by providing the best intervention (DTT, JASPER and CET) for children who need it (leading to individualized sequences of intervention), only when it is needed (potentially reducing burden on children).
Key facts
- Study ID
- NCT03883139
- Run by
- University of California, Los Angeles
- People needed
- 140
- Starts
- 2021-03-01
- Expected to finish
- 2027-09-30
- Last updated by the study team
- 2026-07-16
Who can join
Age: 3 and older, up to 5. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- children meeting ADOS-2 criteria for ASD,
- age 36-59 months
- who have had > 3 months early intervention/preschool (to ensure that children already have been exposed to some community interventions) and
- use < 20 functional words (i.e., non-echoed, non-scripted).
- Additional inclusion criteria are:
- stable medication over the past 6 months, and
- nonverbal mental age of >12 months on the Mullen Scales of Early Learning (visual reception and fine motor subscales).
You may not qualify if…
- We will exclude children who have sensory and motor impairments (e.g., visual impairment, deaf or hard of hearing) and with known genetic syndromes (e.g., Down Syndrome).
- We will not exclude on the basis of AAC exposure, but expect few will be exposed at these ages.
Where it is running
- UCLA — Los Angeles, California, United States
- University of Rochester — Rochester, New York, United States
- University of Oregon — Eugene, Oregon, United States
Full record on ClinicalTrials.gov
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