Induced-T Cell Like NK Cellular Immunotherapy for Cancer Lack of MHC-I
Recruiting now · Phase 1/Phase 2
Conditions studied: Anti-cancer Cell Immunotherapy, T Cell and NK Cell
In brief
T effector cells and NK cells have mutual compensatory killing functions on various of cancer types. For those cancers that have no available targets for CAR-T cell generations, we established potent T cell-like NK cells (ITNK) with a specific conversion protocol for the T cells from the patient, to perform anti-cancer therapy, especially for those cancers that are lack of MHC-I molecule expression. We have finished pre-clinical investigations for the ITNK or CAR-ITNK cell therapy and scheduled to start a clinical phase I study.
Key facts
- Study ID
- NCT03882840
- Run by
- Second Affiliated Hospital of Guangzhou Medical University
- People needed
- 60
- Starts
- 2019-01-01
- Expected to finish
- 2035-01-01
- Last updated by the study team
- 2024-06-26
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients with advanced cancer, which express low or no MHC-I.
- Life expectancy >12 weeks
- Adequate heart,lung,liver,kidney function
- Available autologous T cells
- Informed consent explained to, understood by and signed by patient/guardian. 6. Patient/guardian given copy of informed consent.
You may not qualify if…
- Had accepted gene therapy before;
- Severe virus infection such as HBV,HCV,HIV,et al
- Known HIV positivity
- History of liver or other organ transplantation
- Active infectious disease related to bacteria, virus,fungi,et al
- Other severe diseases that the investigators consider not appropriate;
- Pregnant or lactating women
- Systemic steroid treatment (greater than or equal to 0.5 mg prednisone equivalent/kg/day)
- Other conditions that the investigators consider not appropriate.
Where it is running
- The Second Affiliated Hospital of Guangzhou Medical University — Guangzhou, Guangdong, China (enrolling)
Full record on ClinicalTrials.gov
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