4-methylpyrazole and Acetaminophen Metabolism

Completed · Early Phase 1

Conditions studied: Healthy Adult Volunteers

In brief

Oxidative metabolism of APAP will be studied with and without 4-MP.

Key facts

Study ID

NCT03878693

Run by

University of Arizona

People needed

6

Starts

2018-07-01

Expected to finish

2018-10-31

Last updated by the study team

2019-09-26

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Healthy
• No APAP use in previous 2 weeks
• No ingestion of alcohol or drugs that affect CYP 2E1 over previous 5 days
• No allergy to APAP or fomepizole
• BMI < 29

You may not qualify if…

• Pregnant or lactating
• History of alcohol abuse
• Allergy to APAP or fomepizole
• Screening LFTs above normal range

Where it is running

• BUMCP - Department of Medical Toxicology — Phoenix, Arizona, United States

Full record on ClinicalTrials.gov

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