Acute Control of Chronic Hypertension

Stopped early · Phase 4

Conditions studied: Preeclampsia With Severe Features, Chronic Hypertension in Obstetric Context

In brief

The purpose of this study is to understand if administration of a personalized dose of the anti-hypertensive medication, labetalol, based on patient's history of preexisting hypertension, will be more effective at controlling severe hypertension during pregnancy, compared to the current standard dosing.

Key facts

Study ID

NCT03877692

Run by

Albany Medical College

People needed

10

Starts

2019-02-18

Expected to finish

2020-07-20

Last updated by the study team

2020-07-22

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥ 18 years
• Gestational age ≥ 24 weeks
• Singleton gestation
• Chronic hypertension as defined as two elevated blood pressures (SBP ≥ 140mmHg and/or DBP ≥ 90mmHg) at least 4 hours apart before 20 weeks gestation

You may not qualify if…

• Known allergic reaction to labetalol
• Persistent mild-moderate asthma (≥ 2 rescue inhaler uses per week in the previous month)
• Obstructive airway disease
• Bradycardia < 70 beats/min
• Heart block > 1st degree or history of heart failure

Where it is running

• Albany Medical Center Obstetrics and Gynecology — Albany, New York, United States

Full record on ClinicalTrials.gov

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