Analysis of Biopsy Specimens to Study Responses to PD-1 or PD-L1 Therapies

Withdrawn before enrolling

Conditions studied: Non Small Cell Lung Cancer

In brief

The purpose of this study is to attempt to obtain an on-treatment biopsy in participants with non-small cell lung cancer who are receiving standard treatment with a drug that targets the PD-1 or PD-L1 protein.

Key facts

Study ID

NCT03877250

Run by

Memorial Sloan Kettering Cancer Center

People needed

0

Starts

2019-03-08

Expected to finish

2020-08-26

Last updated by the study team

2025-05-15

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Pathologically confirmed newly diagnosed or recurrent advanced Non Small Cell Lung Cancer/NSCLC that is PI-L1 high by immunohistochemistry (PD-L1 >/= 50%)
• Intended treatment with a PD-(L)1 inhibitor
• Age >/= 18 years
• Karnofsky Performance Status >/= 70% and medically fit to undergo a biopsy procedure

You may not qualify if…

• Any medical condition or any sites of disease that would preclude a biopsy
• Pregnant or breastfeeding women
• Cognitively impairment affecting ability to understand and provide informed consent
• Prior PD-(L)1 blockade treatment
• Chemotherapy within 6 months prior to enrollment

Where it is running

• Memoral Sloan Kettering Basking Ridge (Consent and Follow up) — Basking Ridge, New Jersey, United States
• Memoral Sloan Kettering Monmouth (Consent and Follow up) — Middletown, New Jersey, United States
• Memorial Sloan Kettering Bergen (Consent and Follow up) — Montvale, New Jersey, United States
• Memorial Sloan Kettering Cancer Center @ Suffolk (Consent Only) — Commack, New York, United States
• Memoral Sloan Kettering Westchester (Consent & Follow Up) — Harrison, New York, United States
• Memorial Sloan - Kettering Cancer Center (Consent and follow-up) — New York, New York, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.