Plasma TMAO and Choline Levels in Individuals With Metabolic Syndrome - Comparison Between Eggs and Choline Supplement.

Completed · Not applicable

Conditions studied: Coronary Artery Disease, Diabetes, Metabolic Syndrome

In brief

The objective of this study is to determine the effects of consuming either 3 eggs per day and compare it to daily choline supplement (choline bitartrate) for a dose of approximately 400 mg/day on plasma concentrations of high density lipoprotein cholesterol (HDL-c), trimethylamine N oxide (TMAO) and plasma choline. The goal is to determine if choline given as phosphatidyl choline (from eggs) will have a more beneficial effect on plasma choline and microbiota.

Key facts

Study ID: NCT03877003
Run by: University of Connecticut
People needed: 25
Starts: 2018-11-01
Expected to finish: 2020-06-30
Last updated by the study team: 2020-11-03

Who can join

Age: 35 and older, up to 70. Sex: any. Healthy volunteers: accepted.

You may qualify if…

All genders
35-70 years
Metabolic syndrome (based on 3 out of 5 characteristics: waist circumference > 88 cm for women and > 102 cm for men, plasma triglycerides > 150 mg/dL, fasting glucose > 100 mg/dL, blood pressure > 135/85 and HDL < 40 mg/dL for men and < 50 mg/dL for women),
willing to consume 3 eggs per day for 4 weeks
willing to consume choline supplement (400 mg/day for 4 weeks)

You may not qualify if…

Self-reported diaberes, cardiovascular disease, history of stroke, liver disease or cancer
Taking glucose lowering medications
Taking antibiotics in the previous 1 month
Triglycerides > 500 mg/dL,
Cholesterol > 240 mg/dL,
blood pressure > 145/100 mm of Hg
Allergic to eggs or to choline

Where it is running

Department of Nutritional Sciences — Storrs, Connecticut, United States
University of Connecticut — Storrs, Connecticut, United States

Full record on ClinicalTrials.gov

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