Genetics of Spontaneous Coronary Artery Dissection (SCAD-INSPIRE Genetics)

Enrolling by invitation

Conditions studied: Spontaneous Coronary Artery Dissection

In brief

Spontaneous coronary artery dissection (SCAD) is a rare cause of coronary ischemia and infarction where a tear in blood vessel wall either restricts the flow of blood or the blood becomes trapped in between the layers of the vessel causing the vessel to impinge on the lumen and causing an obstruction or restriction of blood flow. The ultimate goal of this proposal is to further understand the risk factors leading to SCAD with a focus on familial and genetic causes of SCAD.

Key facts

Study ID

NCT03876847

Run by

Intermountain Health Care, Inc.

People needed

100

Starts

2016-10-17

Expected to finish

2036-12-31

Last updated by the study team

2026-04-14

Who can join

Age: any. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• SCAD Cases
• Subjects of all ages, gender, or race
• Subjects had coronary angiography.
• Subjects had suspected SCAD as based on clinical report.
• Controls
• INSPIRE subject that had coronary angiography at Intermountain Healthcare for stable angina.
• Subjects had no or mild atherosclerotic heart disease at time of angiography.
• Age at last visit as recorded in the Intermountain EDW at least 50 years or older.
• Not screened as possibly having a SCAD or coronary artery dissection diagnosis.

You may not qualify if…

• SCAD Cases
• Independent review of cardiac imaging and clinical presentation by three cardiologists determine the coronary angiography was not a result of SCAD.
• Imaging from time of coronary angiography of poor quality as to not allow for proper determination of SCAD.
• Inability to determine criteria as outlined above.
• Subjects that have had a heart transplant.
• Subjects that have had a bone marrow transplant.
• Inability or refusal of the patient and/or the patient's legally acceptable representative to provide informed consent or blood sample for any reason.
• Other conditions that in the opinion of the Principal Investigator may increase risk to the subject and/or compromise the quality of the trial.
• Controls
• Subjects that have a heart transplant.
• Subjects that have a bone marrow transplant.
• Subjects with any of the following diagnosis at anytime
• Heart failure
• Heart valve disease
• Thoracic aortic aneurysm and dissection
• Ehlers-Danlos syndrome
• Shprintzen-Goldberg syndrome
• Marfan syndrome
• Loeys-Dietz aortic aneurysm syndrome
• Arterial tortuosity syndrome

Full record on ClinicalTrials.gov

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