Physical Activity, Alzheimer's Disease and Cognition Relative to APOE Genotype

Completed · Not applicable

Conditions studied: Healthy, Dementia, Alzheimer Disease, Physical Activity

In brief

Physical activity and Alzheimer's disease (PAAD-2) is a randomized control trial that will assess the effects of exercise on middle-aged (40-65 years) cognitively normal adults who have a heightened risk of Alzheimer's disease (AD) due to family history (FH+). The investigators will also assess the extent to which this effect is moderated by apolipoprotein epsilon-4 (APOE4) carrier status, and will gather critical new experimental evidence on the use of physical activity to improve cognitive performance by persons at the greatest risk of Alzheimer's disease.

Key facts

Study ID

NCT03876314

Run by

University of North Carolina, Greensboro

People needed

180

Starts

2019-05-23

Expected to finish

2024-12-21

Last updated by the study team

2026-06-12

Who can join

Age: 40 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Family History of Alzheimer's disease, cognitive impairment
• Able to communicate in English
• Not currently meeting recommendations for physical activity (the recommendations are to exercise 3 days/week for 30+ minutes per day for longer than 3 months)
• Willing to be randomized to either study condition
• Willing to complete all study activities for 1 year

You may not qualify if…

• Meet the criteria for clinical cognitive impairment
• Unable to perform physical activity due to known cardiovascular, metabolic, or renal disease and are symptomatic or due to orthopedic limitations
• Self-report history of confounding neurologic, psychiatric, or active severe or functionally disabling neurologic or medical diseases, or any other conditions that might limit exercise or pose a danger to the patient
• Current use of medications to treat symptoms of Alzheimer's disease, that adversely affect cognition, or that impact heart rate
• Meet the criteria for depression using the short form of the Center for Epidemiological Studies Depression Scale
• Traveling for an extended period (>1 month) during the course of the study

Where it is running

• University of North Carolina-Greensboro — Greensboro, North Carolina, United States

Full record on ClinicalTrials.gov

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