Intermittent Pneumatic Compression With and Without Exercise to Improve Functioning in Peripheral Artery Disease

Running, not enrolling · Not applicable · Has a placebo group

Conditions studied: Peripheral Artery Disease

In brief

The INTERCEDE randomized trial will establish whether six-months of intermittent pneumatic compression combined with walking exercise improves walking endurance at six-month follow-up, compared to walking exercise + sham compression therapy, in people with lower extremity peripheral artery disease (PAD). The INTERCEDE trial will also determine whether intermittent pneumatic compression therapy improves walking endurance at 6-month follow-up, compared to a sham compression therapy. The trial will also determine whether benefits of intermittent pneumatic compression persist after intermittent pneumatic compression treatment is completed.

Key facts

Study ID: NCT03871075
Run by: Northwestern University
People needed: 211
Starts: 2019-01-02
Expected to finish: 2027-04-01
Last updated by the study team: 2026-06-04

Who can join

Age: 55 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

All participants will have PAD. PAD will be defined as follows: first, an ankle-brachial index (ABI) < or = 0.90 at the baseline study visit is an inclusion criterion for PAD. Second, potential participants with an ABI >0.90 who have vascular laboratory evidence of PAD. Vascular laboratory evidence consists of objective evidence of PAD, including toe brachial index (TBI) < or = 0.70, Duplex measure showing 70% stenosis or greater, or ABI values < 0.90. Abnormal waveforms or pulse volume recordings alone from a non-invasive vascular laboratory test will not be sufficient for enrollment. Third, potential participants with an ABI >0.90 who have angiographic evidence of PAD consisting of a stenosis of 70% or greater in a lower extremity artery.

You may not qualify if…

Above- or below-knee amputation.
Critical limb ischemia or ABI < 0.30 in the setting of ischemic symptoms at rest or physical examination findings consistent with critical limb ischemia. Some potential participants with symptoms or signs of critical limb ischemia may be excluded at the principal investigator's discretion if the ABI is 0.30 or higher.
Wheelchair-bound.
Current foot ulcer on bottom of foot.
Walking is primarily limited by a symptom other than PAD.
Failure to successfully complete the study run-in.
Major surgery, revascularization, or orthopedic surgery in the past 3 months or planned in the next 12 months.
Major medical illness including Parkinson's Disease, lung disease requiring oxygen, cancer requiring treatment in the previous two years, or life-threatening illness with a life expectancy of less than six months. Participants who only use oxygen at night will be potentially eligible. [NOTE: potential participants treated for cancer in the past two years may still qualify if they have had treatment for early stage cancer in the past two years and the prognosis is excellent. Potential participants treated for basal cell or squamous cell skin cancer will not be excluded.]
Already exercising at a level consistent with exercise intervention. Current or recent participation in exercise rehabilitation (within the past three months).
Recently diagnosed (within the past three months) with acute lower extremity deep venous thrombosis, pulmonary embolism, or severe heart failure (i.e. New York Heart Association (NYHA) Class III or IV).
Mini-Mental Status Examination (MMSE) score <23 or dementia.
Participation in or completion of a clinical trial in the previous three months.
Non-English speaking.
Increase in angina in the past month, angina at rest, or abnormal baseline treadmill stress test. Potential participants may become eligible after an abnormal baseline treadmill stress test if they have evidence of an absence of coronary ischemia based on testing (such as a stress test with imaging or a coronary angiogram) from a test performed with their own physician and if they do not have symptoms of unstable angina. The evidence of absent coronary ischemia, based on an imaging stress test or coronary angiogram, must have been performed within the previous year.
Ongoing infection of the toes, foot, or lower extremity.
Potential participants who started on cilostazol within the last three months. They may be evaluated for eligibility once three months have passed since beginning cilostazol.
Significant peripheral edema, defined as 3+ or greater edema severity, as determined by the principal investigator.
BMI >45 kg/M2
Significant visual impairment that interferes with walking.
In addition to the above criteria, investigator discretion will be used to determine if the trial is unsafe or not a good fit for the potential participant.

Where it is running

Northwestern University — Chicago, Illinois, United States
University of Chicago — Chicago, Illinois, United States
Henry Ford Health — Detroit, Michigan, United States
University of Minnesota — Minneapolis, Minnesota, United States

Full record on ClinicalTrials.gov

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