Food First Approach to Stimulate Muscle Protein Synthesis in Healthy Adults

Completed · Not applicable

Conditions studied: Hypertrophy

In brief

In a crossover design 10 young healthy adults (20-35 y) will receive stable isotope tracer infusions and perform a single bout of resistance exercise. Immediately after exercise participants will ingest either 3.5 oz of Salmon fillet or its constituent macronutrients as isolated amino acids and fat. Repeated blood and breath samples as well as muscle biopsies will be collected to determine whole body amino acid kinetics, muscle amino acid transporters, anabolic signalling and myofibrillar protein synthesis rates during the trials

Key facts

Study ID

NCT03870165

Run by

University of Illinois at Urbana-Champaign

People needed

10

Starts

2019-03-01

Expected to finish

2019-11-22

Last updated by the study team

2020-09-28

Who can join

Age: 20 and older, up to 35. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age 20-35 years
• Recreationally-active adults: ≥ 30 min of physical activity at moderate intensity ≥ 3 times per week
• English fluency

You may not qualify if…

• Smoking
• Known allergies to fish consumption
• Vegans
• Diagnosed GI tract diseases
• Arthritic conditions
• A history of neuromuscular problems
• Diagnosed cognitive impairments
• Recent (1 year) participation in amino acid tracer studies
• Predisposition to hypertrophic scarring or keloid formation
• Individuals on any medications known to affect protein metabolism (i.e. corticosteroids, non-steroidal anti-inflammatories, or prescription strength acne medications).
• High blood pressure (Systolic > 140 mm HG; Diastolic > 90 mm HG)
• Alcohol consumption >10 drinks per week
• Metabolic disorders (e.g., Metabolic Syndrome, diabetes, thyroid diseases)
• Consumption of thyroid, androgenic or other medications known to affect endocrine function
• Consumption of ergogenic-leves of dietary supplements that may affect muscle mass (e.g., creatine, HMB), insulin-like substances, or anabolic/catabolic pro-hormones (e.g., DHEA) within 6 weeks prior to participation
• Currently pregnant
• A suboptimal diet quality score as assessed by ASA24 dietary records
• Asthma
• Hypogonadism
• Cardiovascular disease, arrhythmias

Where it is running

• Freer Hall — Urbana, Illinois, United States

Full record on ClinicalTrials.gov

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