Study Evaluating the Efficacy and Safety of Multiple Immunotherapy-Based Treatments and Combinations in Patients With Urothelial Carcinoma (MORPHEUS-UC)
Stopped early · Phase 1/Phase 2
Conditions studied: Urothelial Carcinoma, Bladder Cancer
In brief
A Phase Ib/II, open-label, multicenter, randomized, umbrella study in participants with MIBC and in participants with locally advanced or metastatic Urothelial Carcinoma (UC) who have progressed during or following a platinum-containing regimen. The study is designed with the flexibility to open new treatment arms as new treatments become available, close existing treatment arms that demonstrate minimal clinical activity or unacceptable toxicity, or modify the participant population (e.g., with regard to prior anti-cancer treatment or biomarker status). Participants in the mUC Cohort who experience loss of clinical benefit or unacceptable toxicity during Stage 1 may be eligible to continue treatment with a different treatment regimen for Stage 2.
Key facts
- Study ID
- NCT03869190
- Run by
- Hoffmann-La Roche
- People needed
- 272
- Starts
- 2019-06-01
- Expected to finish
- 2025-12-22
- Last updated by the study team
- 2026-08-03
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- UCLA Department of Medicine — Los Angeles, California, United States
- UCSF Comprehensive Cancer Ctr — San Francisco, California, United States
- Stanford Cancer Center — Stanford, California, United States
- University of Kentucky Chandler Medical Center — Lexington, Kentucky, United States
- Norton Cancer Institute — Louisville, Kentucky, United States
- Memorial Sloan-Kettering Cancer Center — Commack, New York, United States
- Levine Cancer Institute — Charlotte, North Carolina, United States
- University Hospitals Cleveland Medical Center — Cleveland, Ohio, United States
- Cleveland Clinic — Cleveland, Ohio, United States
- The University of Texas MD Anderson Cancer Center — Houston, Texas, United States
- Centre Francois Baclesse — Caen, France
- Centre Leon Berard — Lyon, France
- Institut régional du Cancer Montpellier — Montpellier, France
- Institut Claudius Regaud — Toulouse, France
- Attiko Hospital University of Athens — Athens, Greece
- Athens Medical Center — Athens, Greece
- Seoul National University Hospital — Seoul, South Korea
- Asan Medical Center — Seoul, South Korea
- Severance Hospital — Seoul, South Korea
- Complejo Hospitalario Universitario de Santiago (CHUS) — Santiago de Compostela, LA Coruna, Spain
- Clinica Universitaria de Navarra — Pamplona, Navarre, Spain
- Vall d?Hebron Institute of Oncology (VHIO), Barcelona — Barcelona, Spain
- Hospital Clinic i Provincial — Barcelona, Spain
- Institut Catala d Oncologia Hospitalet — Barcelona, Spain
- Hospital Universitario Reina Sofia — Córdoba, Spain
Full record on ClinicalTrials.gov
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