Post-op Ketamine Study

Status unconfirmed · Not applicable · Has a placebo group

Conditions studied: Osteo Arthritis Knee

In brief

The purpose of this study is to establish the effect of sub-anesthetic dosing of ketamine with spinal anesthesia during total knee arthroplasty on post-operative pain and narcotic consumption. We hypothesize that sub-anesthetic ketamine will decrease post-operative pain and narcotic consumption and may secondarily lead to shorter lengths of stay, faster rehabilitation, improved postoperative outcomes and patient satisfaction.

Key facts

Study ID

NCT03865550

Run by

Rothman Institute Orthopaedics

People needed

75

Starts

2016-03-28

Expected to finish

2019-04-27

Last updated by the study team

2019-03-07

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• 18 - 85 years of age
• ASA I - IV
• Undergoing primary unilateral elective total knee arthroplasty with spinal anesthesia

You may not qualify if…

• BMI over 40*
• Contraindication or allergy to opioid pain medication or ketamine*
• Daily opioid use for pain control before surgery in excess of systemic morphine equivalent to 10 mg*
• Ejection fraction (EF) less than 30%
• Creatinine clearance less than 30 mL/min*
• History of chronic liver failure
• Desire for nerve block or general anesthesia
• Any neurologic or psychiatric disorder (including bipolar disorder, post traumatic stress disorder, schizophrenia)
• Prior surgery on ipsilateral knee within the last 6 months
• Alcohol abuse

Where it is running

• Rothman Institute — Philadelphia, Pennsylvania, United States

Full record on ClinicalTrials.gov

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