Reliability of Paired Associative Stimulation-induced Neuroplasticity After Stroke

Stopped early · Not applicable · Has a placebo group

Conditions studied: Stroke

In brief

Paired associative stimulation (PAS) is a non-invasive stimulation method which is known to modulate corticospinal excitability through mechanisms related to long-term potentiation and long-term depression. The purpose of this study is to determine the reliability of individual subject's response (i.e., change in corticospinal excitability) to PAS in patients with chronic stroke (\>6 months) with upper limb motor deficits.

Key facts

Study ID

NCT03861806

Run by

Burke Medical Research Institute

People needed

15

Starts

2019-04-17

Expected to finish

2022-09-12

Last updated by the study team

2022-11-21

Who can join

Age: 19 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Unilateral ischemic stroke with residual arm weakness (Fugl-Meyer Upper Limb < 60) more than 6 months prior to enrollment.
• Ability to give informed consent and understand the tasks involved.
• Age over 18 years.

You may not qualify if…

• Hemorrhagic Stroke
• Contraindications to TMS: history of seizure/epilepsy, pacemaker, other neurological disorders, brain surgery, metal implant/fragment in the head, pregnancy
• Taking medications or substances that are known to affect PAS-induced plasticity within the past 2 months: selective serotonin reuptake inhibitors, dopamine, dopamine agonists, haloperidol, lithium, acetylcholinesterase inhibitors, beta-blockers, nimodipine, levetiracetam, ethosuximide, benzodiazepines, baclofen, nicotine
• Peripheral neuropathy or history of nerve injury in the paretic upper limb.
• Social and/or personal circumstances that interfere with ability to return for all study visits.

Where it is running

• Burke Neurological Institute — White Plains, New York, United States

Full record on ClinicalTrials.gov

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