Opioids Versus Non-Opioids Postoperative After Knee Arthroscopic Surgery
Recruiting now · Phase 4
Conditions studied: Knee Injuries, Pain, Postoperative, Opioid Use
In brief
The purpose of this study is to look at pain management with opioids versus non-opioids after knee arthroscopy. This study will determine 1) whether the most commonly used non-narcotic medications provide pain relief comparable with the most commonly prescribed narcotic medications in patients undergoing arthroscopic knee surgery, and 2) whether patients' characteristics (gender, pre-operative knee symptoms, workers compensation status and employment status) affect pain level following surgery or medication usage.
Key facts
- Study ID
- NCT03858231
- Run by
- Sanford Health
- People needed
- 148
- Starts
- 2018-10-29
- Expected to finish
- 2028-01-01
- Last updated by the study team
- 2026-02-10
Who can join
Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Subjects ≥ 18 years of age through ≤ 80 years of age
- Subjects undergoing elective arthroscopic knee surgery, to include partial meniscectomy, chondroplasty, or loose body removal.
You may not qualify if…
- Previously enrolled in this study (enrolled for contralateral knee in this study)
- Knee arthroscopy patients scheduled for knee ligament reconstructions
- Bilateral knee arthroscopy
- History of chronic opioid use or long-term analgesic therapy
- Documented or suspected substance abuse
- Documented or suspected chronic pain syndrome
- Any known allergy or adverse reaction or contraindication to the components of hydrocodone, acetaminophen, or ibuprofen
- History or symptoms of any significant medical problem in the last year (i.e., arrhythmia, impaired cardiovascular function, gastrointestinal bleeding, liver disease, renal disease)
- With active peptic ulcer disease (history of severe heartburn)
- Symptoms of infection with initial enrollment
- Pregnant or nursing
- Diagnosis of cognitive impairment
- Unable or unwilling to provide informed consent for surgery or enrollment in this clinical study
- Inability to understand the requirements of the study or be unwilling to provide written informed consent (as evidenced by signature on an informed consent document approved by Institutional Review Board) and agree to abide by the study restrictions.
- Patient refusal
- Currently taking Coumadin, Plavix, anticoagulation medications, or medications that increase bleeding, with the exception of ASA 81mg.
- Patients with other medical or psychological health conditions that preclude them from either receiving the intervention or returning for follow-up visits.
- Alcoholism
Where it is running
- Sanford Health — Fargo, North Dakota, United States (enrolling)
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.