Research Study Investigating How Well NNC0174-0833 Works in People Suffering From Overweight or Obesity.

Completed · Phase 2 · Has a placebo group

Conditions studied: Overweight, Obesity

In brief

This study will look at the change in body weight in people taking NNC0174-0833, liraglutide and "dummy" medicine, from the start to the end of the study. As well as taking the medicine, participants will have talks with study staff about healthy food choices, how to be more physically active and what participants can do to lose weight. Participants will either take NNC0174-0833, liraglutide or "dummy" medicine - which treatment participants get is decided by chance. Participants will need to take one injection once a week or once a day, depending on the treatment. The study medicine is injected with a thin needle in a skin fold in the stomach, thigh or upper arm. The study will last for about 8 months. Participants will have 12 clinic visits with the study doctor.

Key facts

Study ID

NCT03856047

Run by

Novo Nordisk A/S

People needed

706

Starts

2019-03-01

Expected to finish

2021-03-25

Last updated by the study team

2024-07-05

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• 18 years or older at the time of signing the informed consent.
• Female subject of non-childbearing potential or Male subject who is surgically sterilised (vasectomy) or who is willing to use adequate contraceptive methods (as required by local regulation or practice) throughout the trial (until 'end of trial').
• BMI equal to 30.0 kg/m\^2 or greater or BMI equal to 27.0 kg/m\^2 or greater with the presence of at least one of the following weight-related comorbidities (treated or untreated): hypertension or dyslipidaemia (to be assessed at the investigator's discretion).

You may not qualify if…

• HbA1c equal to 48 mmol/mol (6.5 percentage) or greater as measured by the central laboratory at screening.
• A self-reported change in body weight greater than 5 kg (11 lbs) within 90 days prior to screening irrespective of medical records.

Where it is running

• Encompass Clinical Research — Spring Valley, California, United States
• Nature Coast Clinical Research — Crystal River, Florida, United States
• Jacksonville Center For Clinical Research — Jacksonville, Florida, United States
• South Broward Research LLC — Pembroke Pines, Florida, United States
• St Johns Center For Clinical Research — Ponte Vedra, Florida, United States
• Cedar-Crosse Research Center — Chicago, Illinois, United States
• Centennial Medical Group — Elkridge, Maryland, United States
• Infinity Medical Research — North Dartmouth, Massachusetts, United States
• Rochester Clinical Research, Inc. — Rochester, New York, United States
• PharmQuest — Greensboro, North Carolina, United States
• Prestige Clinical Research — Franklin, Ohio, United States
• Albert J Weisbrot — Mason, Ohio, United States
• Family Practice Center of Wadsworth, Inc. — Wadsworth, Ohio, United States
• Lynn Institute of Norman — Norman, Oklahoma, United States
• Medical University of South Carolina — Charleston, South Carolina, United States
• Spectrum Medical Research, LLC — Gaffney, South Carolina, United States
• Spartanburg Medical Research — Spartanburg, South Carolina, United States
• Holston Medical Group Pc — Bristol, Tennessee, United States
• Texas Diabetes & Endocinology — Round Rock, Texas, United States
• Washington Center For Weight Management And Research,Inc. — Arlington, Virginia, United States
• National Clinical Research Inc. — Richmond, Virginia, United States
• University of Calgary — Calgary, Alberta, Canada
• C-endo Diabetes & Endocrinology Clinic — Calgary, Alberta, Canada
• C-endo Diabetes & Endocrinology Clinic — Edmonton, Alberta, Canada
• Anaheim Clinical Trials, LLC — Anaheim, California, United States

Full record on ClinicalTrials.gov

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