Aging Brain Structure and Memory in Response to Exercise

Completed · Not applicable

Conditions studied: Mild Cognitive Impairment

In brief

This study will measure brain structure through its mechanical properties, assessed with magnetic resonance elastography, and determine whether it improves with aerobic exercise in older adults with low memory abilities. Additionally, this study will determine if memory abilities improve with exercise and if they are related to brain structure. Overall, this project has the potential to identify how brain health is impacted by exercise in older adults.

Key facts

Study ID

NCT03855475

Run by

University of Delaware

People needed

36

Starts

2019-03-01

Expected to finish

2024-03-31

Last updated by the study team

2024-05-14

Who can join

Age: 60 and older, up to 90. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Cognitive function scores consistent with amnestic mild cognitive impairment based on pre-screening evaluation
• age 60-90 years
• MMSE score >24 at time of initial consent

You may not qualify if…

• major psychiatric disorder (e.g. schizophrenia, bipolar disorder, major depression within past two years)
• neurological or autoimmune conditions affecting cognition (e.g. Parkinson's disease, epilepsy, multiple sclerosis, head trauma with loss of consciousness greater than 30 min, large vessel infarct)
• other systemic medical illnesses (e.g. cardiovascular disease, cancer, renal failure, diabetes, chronic obstructive pulmonary disease, liver diseases, hypertension)
• current medication use likely to affect CNS functions (e.g. long active benzodiazepines)
• failed outcome on the baseline graded exercise test
• hypertension (systolic 130+ mmHg OR diastolic 80+ mmHg) from baseline blood pressure measurement
• claustrophobia, metal implants, pacemaker or other factors affecting feasibility and/or safety of MRI scanning
• concussion within last 2 years and more than 3 lifetime concussions
• current smoking (including marijuana) within the past 3 months

Where it is running

• University of Delaware — Newark, Delaware, United States

Full record on ClinicalTrials.gov

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