Placebo-controlled Study to Determine the Safety and Tolerability of Subcutaneous Doses of Sevuparin

Completed · Phase 1 · Has a placebo group

Conditions studied: Safety and Tolerability

In brief

A Double-blind, Placebo-controlled study in Healthy Volunteers to Determine the Safety and Tolerability of Single, Ascending Subcutaneous Doses of Sevuparin

Key facts

Study ID

NCT03853421

Run by

Modus Therapeutics AB

People needed

24

Starts

2019-02-06

Expected to finish

2019-05-06

Last updated by the study team

2019-07-16

Who can join

Age: 18 and older, up to 64. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Informed consent form is signed and dated
• Adult male or female subjects, aged ≥18 to ≤65 years of age inclusive;
• Body mass index ≥19.0 to ≤29.0 kg/m2 and a body weight 50.0-100.0 kg
• Subjects must have a negative pregnancy test and subjects of childbearing potential must either be surgically sterile or be willing to practice a highly effective method of contraception
• Subjects must be in good health, as determined by a medical history, physical examination
• Subjects with no clinically significant and relevant history that could affect the conduct of the study.

You may not qualify if…

• Recent trauma or injury or history of clinically significant bleeding.
• Clinical evidence of significant or unstable medical illness
• Subjects who have received any prescribed systemic or topical medication
• Subjects who have received aspirin, anti-platelet therapy, anticoagulant therapy and prophylactic and therapeutic LMWH or un-fractioned heparin.
• Subjects who have used any non-prescribed systemic or topical medication (including herbal remedies)
• Subjects who have received any medications known to chronically alter drug absorption or elimination processes
• Subjects who are still participating in a clinical study
• Subjects who have donated any blood, plasma or platelets
• Subjects with a significant history of drug allergy
• Subjects who have any clinically significant allergic disease
• Subjects who have a supine blood pressure and supine pulse rate higher than 140/90 mmHg and 100 beats per minute (bpm), respectively, or lower than 90/50 mmHg and 40 bpm, respectively
• Subjects who have an abnormality in the 12-lead ECG that, in the opinion of the investigator, increases the risk of participating in the study, such as QTcF interval > 470 ms, or with sinus rhythm with PR interval <110 ms or >210 ms, confirmed by a repeat ECG.
• Screening transaminases (AST, ALT, GGT) ≥ 1.5 times the ULN; estimated glomerular filtration rate (GFR, MDRD equation) < 60 mL/min; APTT above the normal range, INR above 1.4; absolute platelet count <150,000/μL.
• Male subjects who consume more than 3 units of alcohol per day. Female subjects who consume more than 2 units of alcohol per day.
• Subjects with a positive urine drug screen/alcohol test result
• Subjects who smoke more than 6 cigarettes
• Subjects who have positive hepatitis B or hepatitis C antibody or HIV antibodies.
• Subjects who test positive for HIT antibodies at Screening.
• Any relevant condition, behavior, laboratory value or concomitant medication which, in the opinion of the investigator, makes the subject unsuitable for entry into the study.

Where it is running

• Clinical Pharmacology of Miami (CPMI) — Miami, Florida, United States

Full record on ClinicalTrials.gov

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