Lung-MAP: A Master Screening Protocol for Previously-Treated Non-Small Cell Lung Cancer
Recruiting now · Phase 2/Phase 3
Conditions studied: Previously Treated Non-Small Cell Lung Cancer
In brief
This screening and multi-sub-study randomized phase II/III trial will establish a method for genomic screening of similar large cancer populations followed by assigning and accruing simultaneously to a multi-sub-study hybrid Master Protocol (Lung-MAP). The type of cancer trait (biomarker) will determine to which sub-study, within this protocol, a participant will be assigned to compare new targeted cancer therapy, designed to block the growth and spread of cancer, or combinations to standard of care therapy with the ultimate goal of being able to approve new targeted therapies in this setting. In addition, the protocol includes non-match sub-studies which will include all screened patients not eligible for any of the biomarker-driven sub-studies.
Key facts
- Study ID
- NCT03851445
- Run by
- SWOG Cancer Research Network
- People needed
- 10000
- Starts
- 2019-02-06
- Expected to finish
- 2029-01-28
- Last updated by the study team
- 2026-05-18
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Sutter Auburn Faith Hospital — Auburn, California, United States (enrolling)
- Kaiser Permanente-Baldwin Park — Baldwin Park, California, United States (enrolling)
- Veterans Administration Medical Center - Birmingham — Birmingham, Alabama, United States (enrolling)
- Gulf Health Hospitals Inc/Infirmary Cancer Care - Malbis — Daphne, Alabama, United States (enrolling)
- Thomas Hospital — Fairhope, Alabama, United States (enrolling)
- Sutter Cancer Centers Radiation Oncology Services-Auburn — Auburn, California, United States (enrolling)
- Mobile Infirmary Medical Center — Mobile, Alabama, United States (enrolling)
- Alaska Breast Care and Surgery LLC — Anchorage, Alaska, United States (enrolling)
- Alaska Oncology and Hematology LLC — Anchorage, Alaska, United States (enrolling)
- Alaska Women's Cancer Care — Anchorage, Alaska, United States (enrolling)
- Gulf Health Hospitals Inc/Infirmary Cancer Care - Saraland — Saraland, Alabama, United States (enrolling)
- Katmai Oncology Group — Anchorage, Alaska, United States (enrolling)
- Providence Alaska Medical Center — Anchorage, Alaska, United States (enrolling)
- Anchorage Associates in Radiation Medicine — Anchorage, Alaska, United States (enrolling)
- CTCA at Western Regional Medical Center — Goodyear, Arizona, United States (enrolling)
- Kingman Regional Medical Center — Kingman, Arizona, United States (enrolling)
- Cancer Center at Saint Joseph's — Phoenix, Arizona, United States (enrolling)
- Banner University Medical Center - Tucson — Tucson, Arizona, United States (enrolling)
- University of Arizona Cancer Center-North Campus — Tucson, Arizona, United States (enrolling)
- NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro — Jonesboro, Arkansas, United States (enrolling)
- University of Arkansas for Medical Sciences — Little Rock, Arkansas, United States (enrolling)
- Kaiser Permanente-Anaheim — Anaheim, California, United States (enrolling)
- Kaiser Permanente-Deer Valley Medical Center — Antioch, California, United States (enrolling)
- PCR Oncology — Arroyo Grande, California, United States (enrolling)
- Kaiser Permanente-Bellflower — Bellflower, California, United States (enrolling)
Full record on ClinicalTrials.gov
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