Ciprofloxacin Versus Levofloxacin in Stem Cell Transplant

Completed · Phase 2

Conditions studied: Prophylaxis, Stem Cell Transplant Complications

In brief

Ciprofloxacin and levofloxacin are both in guidelines to use for prophylaxis in autologous and allogeneic Stem cell transplant.Ciprofloxacin was recently replaced by levofloxacin as the preferred agent in some transplant centers. In some small retrospective studies ciprofloxacin prophylaxis was associated with a higher rate of breakthrough gram positive bloodstream infections. However, the optimum oral agent for antibacterial prophylaxis in transplant recipients remains uncertain.

Key facts

Study ID

NCT03850379

Run by

Henry Ford Health System

People needed

308

Starts

2018-03-14

Expected to finish

2024-08-30

Last updated by the study team

2025-10-20

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients 18-75 years of age with a diagnosis of a hematological malignancy. Meet the stem cell transplant program criteria to undergo autologous or allogeneic hematopoietic stem cell transplantation.

You may not qualify if…

• Prolonged QT
• Allergies to ciprofloxacin or levofloxacin

Where it is running

• Henry Ford — Detroit, Michigan, United States

Full record on ClinicalTrials.gov

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