Imaging Oxidative Metabolism and Neurotransmitter Synthesis in the Human Brain
Recruiting now
Conditions studied: Brain Metabolism
In brief
Investigators propose to develop hyperpolarized \[13C\]-labeled pyruvate as potential imaging probes to assess two essential in vivo processes in cerebral metabolism: oxidative metabolism and synthesis of a neurotransmitter in this observational study.
Key facts
- Study ID
- NCT03849963
- Run by
- University of Texas Southwestern Medical Center
- People needed
- 28
- Starts
- 2030-07-30
- Expected to finish
- 2030-12-31
- Last updated by the study team
- 2026-03-12
Who can join
Age: 18 and older, up to 60. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- 18 through 60 years of age.
- Healthy, with no neurological abnormalities.
- Ability to understand and the willingness to sign a written informed consent.
- All races and ethnicities will be included; subjects must be able to read and speak the English language.
You may not qualify if…
- Metallic foreign bodies on the scalp or cranium which may interfere with MRI acquisitions
- Major debilitating neurological disease including, but not limited to, stroke, CVA, dementia and tumor that would limit compliance with study requirements
- Under influence of illicit drugs which are known to alter brain physiology/metabolism including, but not limited to cocaine, lysergic acid diethylamide (LSD), and marijuana at the time of MRI/MRSI scanning.
- Under influence of antiepileptic drugs at the time of MRI/MRSI scanning.
- Any contraindication per MRI Screening Form including
- Implants contraindicated at 3T, pacemakers
- Implantable Cardioverter Defibrillator (ICD)
- Claustrophobia
- Medically unstable including
- Heart failure
- Severe left ventricular outflow tract (LVOT) obstruction
- Unstable angina
- Pregnancy
- Lactating
Where it is running
- UT Southwestern - Advanced Imaging Research Center — Dallas, Texas, United States (enrolling)
Full record on ClinicalTrials.gov
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