Independent and Combined Effects of Resistance Exercise Training and β-hydroxy β-methylbutyrate Plus Vitamin D
Status unconfirmed · Not applicable · Has a placebo group
Conditions studied: Aging, Skeletal Muscle
In brief
During middle-age, humans begin to lose muscle mass and strength. With increasing age the deterioration of muscle health is associated with a decline in quality of life and the loss of independence. β-hydroxy β-methylbutyrate (HMB) plus Vitamin D (VitD) have been proposed to increase skeletal muscle mass, contractile function and improve body composition but has yet to be evaluated in middle-aged women. The overall goal of this study is to determine the effects of HMB +VitD supplementation during 12 weeks of resistance exercise training or a non-exercise control on body composition, skeletal muscle size, and skeletal muscle function in middle-aged women.
Key facts
- Study ID
- NCT03848741
- Run by
- University of Illinois at Urbana-Champaign
- People needed
- 48
- Starts
- 2019-04-01
- Expected to finish
- 2021-04-01
- Last updated by the study team
- 2019-07-17
Who can join
Age: 45 and older, up to 60. Sex: female. Healthy volunteers: accepted.
You may qualify if…
- Women between 45 and 60 years old
- Women with a BMI < 35 kg/m2
- Sedentary (< 30 minutes of structured physical activity 3 times per week)
- Weight stable for 3 months prior (+/- 5kg)
You may not qualify if…
- Body mass index > 35 kg/m2
- Type 1 or Type 2 diabetes
- Uncontrolled hypertension
- Active cancer, cancer in remission, or having received treatment for any form of cancer in the previous 5 years
- Cardiovascular disease (e.g., peripheral artery disease and peripheral vascular disease)
- Uncontrolled thyroid function
- Chronic and/or regular consumption of medication known to influence skeletal muscle metabolism
- Use of Vitamin D (>2000 IU) or β-hydroxy β-methylbutyrate
- Tobacco use
- Any condition that limits exercise training (e.g., chronic obstructive pulmonary disease, neuromuscular disorder, moderate or severe cognitive impairment, Alzheimer's disease, vertigo, dizziness)
- High alcohol consumption defined as more than 8 drinks per week for women
- Unwilling to undergo any study-related procedures
- Pregnancy
- Abnormal liver or kidney enzymes determined in blood chemistry panel
- Bleeding/clotting disorders or blood thinning medications (e.g., warfarin, heparin)
Where it is running
- Freer Hall — Urbana, Illinois, United States (enrolling)
Full record on ClinicalTrials.gov
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