FQ Restriction for the Prevention of CDI
Completed
Conditions studied: Clostridium Difficile, Clostridium Difficile Infection, C Difficile Colitis
In brief
This study evaluates the effectiveness of a new intervention, fluoroquinolone (FQ) Preprescription Authorization (PPA) strategy, to reduce and prevent Clostridium difficile infection (CDI) in hospital intensive care units (ICUs). The investigators will model a successful FQ PPA strategy in several Wisconsin ICUs and compare whether the intervention has improved outcomes in reducing CDIs. An additional goal of the study is to evaluate environmental and work system factors using systems engineering models in order to determine the most successful way to implement these new strategies.
Key facts
- Study ID
- NCT03848689
- Run by
- University of Wisconsin, Madison
- People needed
- 5871
- Starts
- 2019-05-01
- Expected to finish
- 2024-05-31
- Last updated by the study team
- 2025-01-31
Who can join
Age: any. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Medical-surgical intensive care unit with at least 10 beds
- Presence of existing antibiotic stewardship (AS) program with pharmacist and ID physician support
- Electronic health record (EHR) vendor is Epic Systems Corporation
- Has ability to extract antibiotic usage data (days of therapy)
- Has ability to extract required outcomes data (CDI, mortality, length of ICU stay)
- Ability to extract or abstract data on indications for antibiotic use
- Adherence to best practices for infection control relevant to CDI
You may not qualify if…
- Medical-surgical intensive care units with a FQ restriction in place as part of their usual care procedures will be excluded.
Where it is running
- Mayo-Arizona — Phoenix, Arizona, United States
- Riverside University Health System Medical Center — Moreno Valley, California, United States
- Mayo-Rochester — Rochester, Minnesota, United States
- St. Luke's Health System — Kansas City, Missouri, United States
- University of Texas Medical Branch at Galveston — Galveston, Texas, United States
- Gundersen Health Systems — La Crosse, Wisconsin, United States
- University of Wisconsin Hospital & Clinics — Madison, Wisconsin, United States
Full record on ClinicalTrials.gov
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