Brain Markers Predicting Reading Recovery After Stroke
Completed
Conditions studied: Left-Hemisphere Stroke
In brief
For millions of stroke survivors acquired reading deficits represent a significant handicap preventing them from returning to work or continuing their education. The goal of the proposed research is to investigate what brain mechanisms enable recovery of impaired reading. To achieve this goal, the project will directly measure changes in brain perfusion (blood flow) and activation among recovering stroke survivors using a neuroimaging technique called perfusion fMRI (functional Magnetic Resonance Imaging). The project will test if re-perfusion (return of circulation) and re-appearance of reading-related brain activity in the left-brain network for reading is associated with recovery. The ability to predict recovery from neuroimaging has tremendous value in rehabilitation for generating prognoses. It may also dramatically improve the quality of research evaluation for novel, targeted interventions such as noninvasive brain stimulation or pharmacologic therapies.
Key facts
- Study ID
- NCT03845686
- Run by
- Kessler Foundation
- People needed
- 26
- Starts
- 2018-04-04
- Expected to finish
- 2021-07-01
- Last updated by the study team
- 2021-08-31
Who can join
Age: 18 and older, up to 100. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- age >18 years
- right-handed
- fluent and literate in English prior to stroke
- no prior neurological disorders or clinical stroke event
- <4 weeks post-stroke
- ability to undergo an MRI and complete study tasks
- presence of reading deficits
You may not qualify if…
- participants with severe aphasia resulting in severe language deficits and inability to consent
- participants with very large lesions resulting in severe cognitive deficits and inability to consent
Where it is running
- Kessler Foundation — West Orange, New Jersey, United States
Full record on ClinicalTrials.gov
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