Role of Sweetness in Glucose Regulation

Status unconfirmed · Not applicable

Conditions studied: Obesity

In brief

Data from several studies show that consuming a diet high in low-calorie sweeteners (LCS), mainly in diet sodas, is linked to the same metabolic disorders as consuming a diet high in added sugars, including an increased risk of developing type 2 diabetes. Sweet taste receptors, once thought to be unique to the mouth, have now been discovered in other parts of the body, including the intestine and the pancreas, where they play a role in blood sugar control. These newly identified receptors provide new avenues to explore how LCS may affect metabolism and health. This project is designed to examine the role of sweet taste signaling, both in the mouth and in the gut, on blood sugar control and how habitual consumption of LCS may affect sweet taste signaling and metabolism in people with obesity.

Key facts

Study ID

NCT03844230

Run by

University of Illinois at Urbana-Champaign

People needed

80

Starts

2019-04-24

Expected to finish

2022-12-31

Last updated by the study team

2021-04-27

Who can join

Age: 21 and older, up to 40. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• All races/ethnicities
• Habitual (> 5 diet sodas per week) and non-habitual (≤1 diet soda or 1 packet of LCS per week) LCS consumers
• 30 ≤ BMI <40 kg/m2
• Not severely insulin resistant (HOMA-IR2 < 2.6)

You may not qualify if…

• BMI < 30 and 40< BMI kg/m2
• HOMA-IR2>2.6
• Irregular LCS consumers (>1 diet sodas or packets of LCS per week but <5)
• Current smokers or quit smoking nicotine cigarettes for less than 6 months ago
• Pregnant, breastfeeding, menopausal
• Presence of anemia : <12g/dl for women and <13g/dl for men
• Blood donation in the past 8 weeks
• Presence of malabsorption syndrome
• History of bariatric surgery
• Presence of inflammatory intestinal disease, liver or kidney disease
• Have diabetes (fasting glucose level >126mg/dl or plasma glucose level 2h after glucose challenge >200 mg/dl)
• Taking any medication that might affect glucose metabolism or the results of our study

Where it is running

• University of Illinois at Urbana Champaign — Champaign, Illinois, United States (enrolling)

Full record on ClinicalTrials.gov

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