Metoclopramide, Azithromycin, or Nondrug Pretreatment for UGIB to Reduce Second Endoscopy

Status unconfirmed · Phase 2 · Has a placebo group

Conditions studied: Gastro Intestinal Bleeding, Upper Gastrointestinal Bleeding

In brief

Early endoscopy is an integral part of the management plan for patients presenting with clinical signs of severe or ongoing UGIB. An accurate endoscopic diagnosis and successful endoscopic hemostasis is highly dependent on adequate visualization of the entire gastric mucosa. Metoclopramide has previously been investigated as a prokinetic agent to aid gastric emptying prior to endoscopy, but its widespread adoption is limited by a lack of high quality clinical evidence as well as concerns regarding side effects. Erythromycin is currently the only prokinetic agent recommended by the American and the European guidelines for use in selected patients in order to reduce the need for second endoscopy. Its clinical application, however, is limited by risk of arrhythmia, significant drug interactions, and frequent drug shortages. Azithromycin is structurally related to erythromycin, but is devoid of most adverse side effects associated with erythromycin use. Early evidence suggests that azithromycin may be an effective alternative to erythromycin in the treatment of gastroparesis. The current study, an interventional, randomized, triple-blinded, placebo-controlled clinical trial, is primarily aimed to evaluate the effectiveness of azithromycin as a prokinetic agent in the management of UGIB. It is also aimed to further evaluate the role of metoclopramide as a prokinetic agent in this setting. Outcome measures to be collected in this study include the need for secondary endoscopy, overall mortality, transfusion requirement, length of stay, requirement for surgery, and incidence of adverse side effects. Results from this study would help identify a safe, effective, and readily available prokinetic agent to be used prior to endoscopy.

Key facts

Study ID

NCT03840057

Run by

Waihong Chung

People needed

435

Starts

2020-07-01

Expected to finish

2021-07-01

Last updated by the study team

2020-08-07

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• 1. Adult patients ≥ 18 years of age at the time of presentation;
• 2. Admitted to Rhode Island Hospital (RIH) emergency room or inpatient services;
• 3. Presented with hematemesis, coffee ground emesis, or melena;
• 4. Upper endoscopy is planned within 24 hours of presentation or onset of bleeding.

You may not qualify if…

• 1. Known anaphylactic allergic reaction to erythromycin, azithromycin, and/or metoclopramide;
• 2. Concurrent use of certain medications associated with tardive dyskinesia (TD):
• a. Fluphenazine,
• b. Haloperidol,
• c. Loxapine,
• d. Paliperidone,
• e. Perphenazine,
• f. Pimozide,
• g. Risperidone,
• h. Thiothixene,
• i. Trifluoperazine;
• 3. Concurrent use of certain medications associated with torsade de pointes:
• a. Amiodarone,
• b. Chlorpromazine,
• c. Disopyramide,
• d. Dofetilide,
• e. Methadone,
• f. Procainamide,
• g. Quinidine,
• h. Sotalol;
• 4. Known history of TD, ventricular arrhythmias , or long QT syndrome;
• 5. Already received erythromycin and/or azithromycin within the past 10 days, or metoclopramide within the past 4 days for other indications;
• 6. Recipient of hematopoietic stem cell transplant;
• 7. History of Neisseria gonorrhoeae infection;
• 8. Pregnancy;

Where it is running

• Rhode Island Hospital — Providence, Rhode Island, United States (enrolling)

Full record on ClinicalTrials.gov

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