Building a Platform for Precision Anesthesia in the Geriatric Surgical Patient

Running, not enrolling

Conditions studied: Cognitive Decline, Cognitive Change, Cognitive Impairment, Postoperative Delirium, Anesthesia; Reaction, Anesthesia; Adverse Effect

In brief

The research team is creating a foundational infrastructure in order to develop a precision medicine approach for geriatric patients who require surgery with anesthesia. The team plans to build the first of its kind comprehensive database of demographic and risk factor questionnaire responses, biobanked blood specimens, intraoperative electroencephalography (EEG), and inclusive cognitive testing throughout patient interaction starting at the preop appointment until a year later. This will be used to create a predictive model of periooperative neurocognitive disorders.

Key facts

Study ID

NCT03839784

Run by

Stanford University

People needed

250

Starts

2020-09-01

Expected to finish

2030-08-30

Last updated by the study team

2026-04-23

Who can join

Age: 65 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• At least 65 years old (inclusive)
• Non cardiac general elective surgery
• General anesthesia is expected for 2+ hours

You may not qualify if…

• Alzheimer's
• Dementia
• Parkinson's
• History of neurodegenerative diseases
• Medication for depression (ie. Benzodiazepines)
• Alcoholism
• Discretion of PI

Where it is running

• Stanford Medical Center — Stanford, California, United States

Full record on ClinicalTrials.gov

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