Tolerability Study of Trichostatin A In Subjects With Relapsed or Refractory Hematologic Malignancies

Recruiting now · Phase 1

Conditions studied: Relapsed or Refractory Hematologic Malignancies

In brief

The aim of this study is to investigate the safety and tolerability of trichostatin A in individuals with relapsed or refractory hematologic malignancies.

Key facts

Study ID

NCT03838926

Run by

Vanda Pharmaceuticals

People needed

42

Starts

2018-09-27

Expected to finish

2027-12-01

Last updated by the study team

2026-03-16

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Subject is ≥ 18 years at the time of signing informed consent;
• Confirmed malignant hematologic disease or lymphoid malignancy that has relapsed or is refractory to standard therapy and has exhausted all available therapies;
• Presence of measurable or evaluable disease;
• Eastern Cooperative Oncology Group (ECOG) performance status of ≤ 2;
• Contraceptives or other approved avoidance of pregnancy measures

You may not qualify if…

• Allogeneic stem cell transplant recipient presenting with graft versus host disease (GVHD) either active or requiring immunosuppression;
• Concomitantly taking anti-cancer therapy (bisphosphonates are permitted);
• Undergone major surgery ≤ 2 weeks prior to starting study drug;
• Evidence of mucosal or internal bleeding;
• Impaired cardiac function or conduction defect;
• Concurrent severe and/or uncontrolled medical conditions

Where it is running

• Vanda Investigational Site — Opole, Poland (enrolling)
• Vanda Investigational Site — Katowice, Poland (enrolling)
• Vanda Investigational Site — Warsaw, Poland (enrolling)
• Vanda Investigational Site — Biała Podlaska, Poland (enrolling)
• Vanda Investigational Site — Krakow, Poland
• Vanda Investigational Site — Skorzewo, Poland
• Vanda Investigational Site — Washington D.C., District of Columbia, United States
• Vanda Investigational Site — Wroclaw, Poland
• Vanda Investigational Site — Lafayette, Indiana, United States
• Vanda Investigational Site — Hackensack, New Jersey, United States
• Vanda Investigational Site — Seattle, Washington, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.