rTMS to Improve Cognition in Parkinson's

Recruiting now · Phase 1/Phase 2 · Has a placebo group

Conditions studied: Parkinson's Disease, Mild Cognitive Impairment

In brief

The purpose of this study is to examine safety, feasibility, and the behavioral and brain effects of a non-invasive treatment, repetitive transcranial magnetic stimulation (rTMS), for Veterans with Parkinson's disease or atypical parkinsonism and mild impairments in their thinking. The hypothesis is that rTMS can improve thinking for people with Parkinson's disease or atypical parkinsonism who are experiencing mild problems with their thinking ability.

Key facts

Study ID

NCT03836950

Run by

VA Office of Research and Development

People needed

56

Starts

2020-04-01

Expected to finish

2028-03-30

Last updated by the study team

2026-04-21

Who can join

Age: 50 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Veterans who seek services at Hines VA Hospital or Jesse Brown VA Medical Center
• Diagnosis of PD or atypical parkinsonism as determined by a neurologist
• Meet criteria for having mild cognitive impairment
• Receiving stable (i.e., no changes in medication and medication dose) medication and who are expected to remain on stable medication for the duration of the RCT
• Speak and read English
• 50 years or older

You may not qualify if…

• Dementia
• Failure to demonstrate decision making capacity
• History of deep brain stimulation surgery
• Severe depression
• Resting head tremor
• Dyskinesia that will interfere with collecting imaging data
• Has congestive heart failure
• Implanted cardiac pacemaker or defibrillator
• Cochlear implant, nerve stimulator, or intracranial metal clips
• Implanted medical pump
• Increased intracranial pressure
• History of claustrophobia
• Metal in eyes/face, shrapnel/bullet remnants in brain
• Participants at potential increased risk of seizure including those who have the following:
• history (or family history) of seizure or epilepsy
• history of stroke, head injury, or unexplained seizures
• presence of other neurological disease that may be associated with an altered seizure threshold
• such as CVA, cerebral aneurysm, dementia, increased intracranial pressure
• Concurrent medication use such as tricyclic antidepressants, neuroleptic medications, any other drug known to lower seizure threshold
• Secondary conditions that may significantly alter electrolyte balance or lower seizure threshold
• No quantifiable motor threshold such that rTMS dosage cannot be accurately deter-mined

Where it is running

• Edward Hines Jr. VA Hospital, Hines, IL — Hines, Illinois, United States (enrolling)
• Jesse Brown VA Medical Center, Chicago, IL — Chicago, Illinois, United States

Full record on ClinicalTrials.gov

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