Dental Pulp Regeneration by Autologous Tissue Transplantation
Withdrawn before enrolling · Not applicable · Has a placebo group
Conditions studied: Dental Pulp Regeneration
In brief
The purpose of this study is to develop new improved therapy for teeth that require root canals due to tooth infection or tooth inflammation. Investigators will recruit total of 50 participants from the age group 7 - 50 at the UCLA School of Dentistry Endodontic clinic. The participants will be divided into two groups, one will receive traditional therapy, which may include root canal or a procedure called "revascularization," which is a procedure trying to regrow the tissue inside the tooth. The other group of participants will receive the test treatment, which will involve harvesting of pulp tissues from the same tooth or other teeth that are planned for extraction. Investigators will prepare these tissues and place the tissues back into the cleaned root canal space with induced bleeding to allow regrowth of the tissue. For all participants, investigators will follow up after 6, 12, and 24 months in a shorter appointment, which may involve taking x-ray and clinical exam.
Key facts
- Study ID
- NCT03833401
- Run by
- University of California, Los Angeles
- People needed
- 0
- Starts
- 2019-02-14
- Expected to finish
- 2021-06-30
- Last updated by the study team
- 2026-07-23
Who can join
Age: 7 and older, up to 50. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Healthy male or female participants at ages of 7 - 50 y.o. presenting with a tooth diagnosed with complete or partial necrosis of the pulp or irreversible pulpitis.
- Participants presenting with donor pulp tissue, either from existing deciduous teeth or from permanent teeth treatment planned for extraction, e.g., second premolars for orthodontic extraction or third molars.
- Participants presenting with irreversible pulpitis and partial necrosis, i.e., visible pulpal tissues during access opening and canal debridement.
- Participants with immature root apices, including those with partially closed apex, that require root canal procedure.
You may not qualify if…
- Participants with any systemic conditions preventing routine dental procedures or requiring medication that interfere with healing or induce bleeding.
- Participants with avulsed, replanted teeth with resultant pulp necrosis.
- Participants with vertical root fracture/cracks.
- Participants with teeth that are not restorable.
Where it is running
- UCLA School of Dentistry — Los Angeles, California, United States
Full record on ClinicalTrials.gov
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