The Impact of Cytochrome P450 Abnormalities in Patients With Delirium.

Completed

Conditions studied: Delirium, Cytochrome P-450 Enzyme System

In brief

Objectives: 1. To examine whether patients with delirium have higher prevalence of cytochrome-P450 abnormalities compared to patients without delirium. 2. To examine whether the severity of delirium is related to a specific cytochrome P450 genotype. 3. To examine the persistence of delirium at 6-8 weeks stratified by presence of cytochrome p450 abnormalities 4. To examine whether delirium persistence is impacted by types of medications administered during their hospital stay.

Key facts

Study ID

NCT03829670

Run by

Wake Forest University Health Sciences

People needed

13

Starts

2019-01-31

Expected to finish

2020-06-24

Last updated by the study team

2024-10-04

Who can join

Age: 18 and older, up to 99. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients age 18 and older admitted to the ALGH (Advocate Lutheran General Hospital) rehabilitation unit
• One or more of the Following Principle Diagnosis:
• Principle stroke diagnosis Principle Cardiac-Post cardiac surgery Principle Spinal surgery
• Non-English speakers are not anticipated. However, there is an available interpreter services already on the unit and this interpreter's services will be utilized. https://www.languageline.com/ However, we will utilize that AHC IRB approved short forms if a potential subject presents itself.

You may not qualify if…

• Stroke patients with any diagnosed aphasia
• Spinal surgery, as a result of trauma
• Pregnant women
• Prisoners
• Patients with dementia (score of greater than 3.3 on short IQCODE questionnaire) (Long Term Cognitive Impairment after Critical Illness, NEJM, 2013, Pandharipande et al.)
• Patients with cirrhosis and liver failure
• Patients with renal failure requiring dialysis
• Recent blood transfusion

Where it is running

• Advocate Health Care — Park Ridge, Illinois, United States

Full record on ClinicalTrials.gov

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