Stress-Induced Inflammation and Reward Processing

Completed · Not applicable · Has a placebo group

Conditions studied: Stress, Psychological

In brief

Anhedonia, or loss of interest or pleasure, is a key feature of depression and transdiagnostic construct in psychopathology. Both theory and compelling evidence from preclinical models implicates stress-induced inflammation as a key psychobiological pathway to anhedonic behavior; however, this pathway has not been demonstrated in human models. Further, although anhedonia may reflect dysregulation in multiple dimensions of reward, the extent to which stress-induced inflammation alters these dimensions is unclear. The current placebo controlled study used a standardized laboratory stressor task to elicit an inflammatory response in a sample of a healthy young women and evaluate effects of stress-induced inflammation on multiple behavioral indices of reward processing.

Key facts

Study ID

NCT03828604

Run by

University of California, Los Angeles

People needed

57

Starts

2017-05-12

Expected to finish

2018-05-09

Last updated by the study team

2019-02-05

Who can join

Age: 18 and older, up to 28. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• English fluency
• Age 18-28
• Biologically female

You may not qualify if…

• Current illness
• Presence or history of major medical conditions
• Current or past diagnosis of alcohol use disorder
• Use of tobacco
• Use of immune-altering medications
• Current pregnancy

Where it is running

• Clinical and Translational Research Center, University of California, Los Angeles — Los Angeles, California, United States

Full record on ClinicalTrials.gov

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