Epinephrine Dose: Optimal Versus Standard Evaluation Trial

Recruiting now · Phase 4

Conditions studied: Cardiac Arrest, Out-Of-Hospital, Sudden Cardiac Arrest, Ventricular Fibrillation, Ventricular Tachycardia-Pulseless

In brief

The objective of this randomized controlled trial is to evaluate the effectiveness of a low cumulative dose of epinephrine compared to a standard cumulative dose of epinephrine during resuscitation from ventricular fibrillation (VF) or ventricular tachycardia (VT) in adult out-of-hospital cardiac arrest (OHCA) patients.

Key facts

Study ID

NCT03826524

Run by

Unity Health Toronto

People needed

3790

Starts

2023-05-24

Expected to finish

2028-12-01

Last updated by the study team

2025-12-11

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Out-of-hospital cardiac arrest treated by paramedics
• Initial recorded cardiac rhythm of VF or pulseless VT, or, AED shock on first analysis administered or witnessed by EMS (paramedic or fire)
• Established intravenous vascular access

You may not qualify if…

• Known or apparent age <18 years
• Initial recorded cardiac rhythm of VF or pulseless VT, or, AED shock on first analysis administered or confirmed by paramedics
• Cardiac arrest due to an obvious non-cardiac primary cause (e.g. blunt or penetrating trauma, exsanguination, burns, drug overdose, drowning, anaphylaxis, sudden asphyxiation, etc.)
• Administration of intramuscular, endotracheal tube, or intraosseous epinephrine
• Prisoners or persons in police custody
• Known allergy or sensitivity to epinephrine

Where it is running

• British Columbia Emergency Health Services (BCEHS) — Victoria, British Columbia, Canada (enrolling)
• Peel Regional Paramedic Services — Brampton, Ontario, Canada (enrolling)
• Middlesex-London Paramedic Service — London, Ontario, Canada (enrolling)
• Halton Region Paramedic Services — Oakville, Ontario, Canada (enrolling)
• Ottawa Paramedic Services — Ottawa, Ontario, Canada (enrolling)
• Superior North Emergency Medical Services — Thunder Bay, Ontario, Canada (enrolling)
• Essex-Windsor Emergency Health Services — Windsor, Ontario, Canada (enrolling)
• Medavie Health Services West — Saskatoon, Saskatchewan, Canada (enrolling)

Full record on ClinicalTrials.gov

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