hUC Mesenchymal Stem Cells (19#iSCLife®-LC) in the Treatment of Decompensated Hepatitis b Cirrhosishepatitis b Cirrhosis

Recruiting now · Phase 1

Conditions studied: Hepatitis B

In brief

1. Evaluation the safety of using human umbilical mesenchymal stem cells to treat patients with hepatitis B cirrhosis. 2. Observe the curative effect of patients with hepatitis B cirrhosis who use human umbilical mesenchymal stem cells to treat. 3. Explore the possible mechanism of human umbilical mesenchymal stem cells to treat patients with hepatitis B cirrhosis.

Key facts

Study ID

NCT03826433

Run by

Sclnow Biotechnology Co., Ltd.

People needed

20

Starts

2018-10-01

Expected to finish

2027-12-31

Last updated by the study team

2026-04-23

Who can join

Age: 18 and older, up to 60. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 18-60 years old, gender not limited, body mass index (BMI) between 19-25 kg/m2, including boundary value;
• The diagnosis of hepatitis B cirrhosis was in line with the 2015 American society of hepatology (AASLD) guidelines for the treatment of chronic hepatitis B, and the liver function grade was child-pugh B or child-pugh C, with a score range of 7-12 points, and Model for End-Stage Liver Disease score≤21 points.
• Have not received stem cell therapy in the recent 6 months;
• Subjects will be able to sign the informed consent in accordance with the study procedures and instructions.

You may not qualify if…

• Insufficiency of vital organs, such as heart, kidney and lung;
• End-stage cirrhosis with severe complications, including but not limited to: hepatic encephalopathy, gastrointestinal bleeding,Severe bleeding tendency, massive ascites, etc.
• Concomitant peritonitis, pneumonia, or other types of infection not under control;
• Have a history of severe allergic reaction or allergy to two or more kinds of food or medicine;
• Positive serum HIV antibody and syphilis antibody;
• Alpha fetoprotein>400ng/mL with primary liver cancer or without imaging evidence;
• Chronic liver disease and cirrhosis are caused by non-chronic hepatitis B virus infection, or other factors except chronic hepatitis B virus infection ;
• Patients with severe mental illness and cognitive impairment;

Where it is running

• Xiangya Hospital Central South University — Changsha, Hunan, China (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.