Auburn University Research on Olive Oil for Alzheimer's Disease (AU-ROOAD)

Completed · Not applicable

Conditions studied: Alzheimer Disease, Cerebral Amyloid Angiopathy

In brief

Until now there is no medical treatment and/or intervention that can slow, stop or reverse the underlying neurodegenerative of Alzheimer's disease (AD). The goal of this study is to demonstrate "Oleocanthal rich-extra-virgin olive oil (EVOO) consumption stops or delay mild cognitive impairment conversion to AD by restoring the blood-brain barrier (BBB) function in humans". Specific Aims: 1. Evaluate effect of EVOO on the brain function by functional MRI (fMRI) imaging, and BBB function by dynamic contrast-enhanced MRI (DCE-MRI). 2. Evaluate effect of EVOO on cognitive function and on selected biomarkers

Key facts

Study ID

NCT03824197

Run by

Auburn University

People needed

25

Starts

2019-05-07

Expected to finish

2020-12-31

Last updated by the study team

2021-08-02

Who can join

Age: 55 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Men and women, experiencing mild cognitive impairment with:
• Mini-Mental State Exam (MMSE) scores between 18-30 (based on education level
• memory complaint, have objective memory loss measured by education adjusted scores on Wechsler Memory Scale Logical Memory VI
• Clinical Dementia Rating (CDR) score 0.5.

You may not qualify if…

• Subjects with contradictions for MRI include: the presence of metal or electronic devices such as metallic joint prostheses, artificial heart valves, an implantable heart defibrillator, a pacemaker, metal clips, cochlear implants, a bullet, shrapnel or any other type of metal fragment; breathing problems or disorders, claustrophobia, inner ear disorders, vertigo or dizziness, tattoos or permanent makeup that contains metal, and body piercing jewelry that cannot be removed.
• Subjects will be excluded if they are smokers
• Subjects who have have clinically important medical or neuropsychiatric comorbidity.
• Subjects who have renal problems or are allergic to the MRI contrast agent.

Where it is running

• Auburn University — Auburn, Alabama, United States

Full record on ClinicalTrials.gov

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