Exercise Training and Time-restricted Feeding in Overweight and Obese Adults

Completed · Not applicable

Conditions studied: Overweight and Obesity, Weight Loss

In brief

Overweight and obesity prevalence in adolescents and adults continues to remain significantly high in the United States. While diet and exercise improve many consequences of obesity, dietary strategies are not always nutrient sufficient and manageable long-term. Thus, highly complaint dietary strategies that lead to fat loss, while maintaining muscle mass, are needed. Time-restricted feeding (TRF) may be an ideal dietary approach for reducing fat mass and cardiovascular disease risk, while diminishing the loss of muscle mass and strength associated with obesity and aging. TRF, unlike continuous energy restriction, does not require a restrictive energy intake10. TRF requires individuals to consume calories within a set window of time (example = 8 hours), inducing a fasting window of 16 hours per day. There are few human studies on TRF that measure their effects in combination with both aerobic and resistance training. One recent study found an 8-hour TRF program (16-hour fast) improved insulin sensitivity, decreased fat mass, and maintained muscle mass in resistance-trained males after 8 weeks. Thus, the feasibility of TRF as dietary approach should be investigated further.The aims of this study are to: 1) determine whether time-restricted feeding (TRF) is an effective dietary strategy for reducing fat mass while preserving fat-free mass with aerobic and resistance training; 2) evaluate potential changes in health-related biomarkers (cardiovascular profile and anabolic-catabolic hormones) and muscle health indicators (mass, strength and quality) after 8 weeks of concurrent training with TRF; and 3) examine the influence of caloric intake and macronutrient consumption on muscle health in the TRF and normal feeding (NF) groups pre- to post-concurrent resistance training.

Key facts

Study ID

NCT03823872

Run by

Kyle Hackney

People needed

21

Starts

2018-10-08

Expected to finish

2020-03-31

Last updated by the study team

2020-08-25

Who can join

Age: 35 and older, up to 60. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Body mass index 25.0-34.9 kg/m2, generally healthy and mobile.

You may not qualify if…

• Currently smoke tobacco.
• e-cigarettes, or used smokeless tobacco.
• Diagnosed neuromuscular disease.
• Diagnosed diabetes,
• Diagnosed high blood pressure.
• Diagnosed cancer.
• Previous heart attack or other chronic heart related conditions.
• Difficulty moving without assistive devices.
• Difficulty walking one quarter mile.
• Taking medications that influence muscle size.
• Previous bariatric surgery.
• Greater than 350 lbs in body mass.
• Currently on a dietary or exercise program.
• At risk for disordered eating via self-report.

Where it is running

• North Dakota State University — Fargo, North Dakota, United States

Full record on ClinicalTrials.gov

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