CyberKnife Dose Escalation Prostate Cancer Trial
Running, not enrolling · Not applicable
Conditions studied: Prostate Cancer, Prostate Adenocarcinoma, Prostate Neoplasm
In brief
Stereotactic body radiation therapy (SBRT) has been employed in the treatment of prostate cancer. Multiple single institution experiences suggest high biochemical control rates with acceptable toxicity in low risk prostate cancer but efficacy data in unfavorable type prostate cancer is less convincing. CyberKnife-SBRT (CK-SBRT) can be used to escalate radiation dose delivery to the prostate while sparing normal tissue.
Key facts
- Study ID
- NCT03822494
- Run by
- Crozer-Keystone Health System
- People needed
- 100
- Starts
- 2018-07-12
- Expected to finish
- 2028-07-12
- Last updated by the study team
- 2025-02-21
Who can join
Age: 18 and older. Sex: male. Healthy volunteers: not accepted.
You may qualify if…
- Histologically confirmed adenocarcinoma of the prostate diagnosed within 360 days of enrollment.
- Prostate Specific Antigen (PSA) documented within 90 days prior to registration.
- Clinical staging completed within 90 days of registration.
- No Nodal or Distant Metastases documented on CT or MRI of the pelvis and bone scan.
- Unfavorable Risk Prostate Carcinoma as Described is documented.
- No prior pelvic radiotherapy.
- No prior Trans-urethral resection of the prostate (TURP).
- Prostate volume < 100 cc
- American Urologic Association (AUA) score < 20
- No recent (within 5 years) or concurrent cancers other than non-melanoma skin cancers.
- Patient must have no medical or psychiatric illnesses that would interfere with treatment or follow-up.
- No implanted hardware adjacent to the prostate that would prohibit appropriate treatment planning and treatment delivery is allowed.
- Candidate for rectal spacer placement
You may not qualify if…
- Other cancer diagnosis other than non-melanoma skin cancer with 5 years
- Prostate size greater than 100cc
- AUA greater than 20
- Implanted hardware impacting imaging
- Metastatic prostate cancer
- Contraindication to hormone therapy
Where it is running
- Philadelphia CyberKnife — Philadelphia, Pennsylvania, United States
Full record on ClinicalTrials.gov
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