Inflammatory Mediators as Potential Non-Invasive Biomarkers in Subjects With Eosinophilic Esophagitis
Running, not enrolling
Conditions studied: Eosinophilic Esophagitis
In brief
The investigators seek to assess esophageal inflammation or lack of it in response to treatment with a novel non-invasive method that would measure eosinophil-associated inflammatory mediators in the blood and urine to determine the presence of active Eosinophilic Esophagitis. For these purposes, the investigators will correlate esophageal inflammatory mediators measured in blood and urine with histological findings identified on esophageal mucosal biopsies. Additionally, biopsies associated mediators will be assessed relative to clinical phenotype and outcome.
Key facts
- Study ID
- NCT03822325
- Run by
- Ann & Robert H Lurie Children's Hospital of Chicago
- People needed
- 88
- Starts
- 2011-02-01
- Expected to finish
- 2027-11-01
- Last updated by the study team
- 2026-06-05
Who can join
Age: 1 and older, up to 18. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Patient ages 1-18 undergoing upper endoscopy for suspected esophageal disease or esophageal inflammation or has histologically confirmed esophageal inflammation may be included in this study
You may not qualify if…
- Patients with a history or current diagnosis of esophageal malignancy or subjects with graft versus host disease will be excluded from the study.
- Patients that are considered at high risk for biopsies at the discretion of the child's physician and/or the researcher
- Patients with known bleeding disorders or patients with illnesses where bleeding would pose a threat to their health
- Diagnosis other than Eosinophilic Esophagitis (EoE) i.e. Inflammatory Bowel Disease (IBD), Gastroesophageal Reflux Disease (GERD)
Where it is running
- Ann & Robert H Lurie Children's Hospital of Chicago — Chicago, Illinois, United States
- University of Illinois at Chicago (UIC) — Chicago, Illinois, United States
Full record on ClinicalTrials.gov
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