Whole Body MRI to Identify Atypical Neurofibromas in Patients With NF1

Running, not enrolling · Not applicable

Conditions studied: Neurofibromatosis 1, Neurofibroma, Atypical Neurofibroma, Atypical Neurofibromatosis, Plexiform Neurofibroma, Von Recklinghausen Disease

In brief

This study is being conducted to determine if Whole Body MRI (WBMRI) can be used to identify Atypical Neurofibromas (ANF) in Neurofibromatosis Type 1 (NF1) patients with high tumor burden. Each enrolled participant will have two (2) WBMRIs without sedation during the study period. Eligible participants must be Male or Female between the ages of 8-30 with diagnosed NF1; with one or more PN greater than 3cm in diameter and willing to comply with study procedures.

Key facts

Study ID

NCT03820778

Run by

Children's National Research Institute

People needed

10

Starts

2018-07-12

Expected to finish

2022-08-01

Last updated by the study team

2021-03-02

Who can join

Age: 8 and older, up to 30. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Males or females between 8-30 years of age
• Confirmed diagnosis of NF1
• Stated willingness to comply with all study procedures and availability for the duration of the study
• Prior MRI documentation confirming >=1 PN that is >3cm in diameter

You may not qualify if…

• Unable to undergo MRI without sedation
• Presence of metal or other devices that are contraindicated for MRI

Where it is running

• Children's National Health System — Washington D.C., District of Columbia, United States

Full record on ClinicalTrials.gov

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