The Use of Hepatitis C Positive Livers in Hepatitis C Negative Liver Transplant Recipients

Completed · Phase 2

Conditions studied: Liver Transplant, Hepatitis C

In brief

This is an open-label, pilot trial to test the safety and efficacy of transplantation of livers from Hepatitis C seropositive non-viremic (HCV Ab+/NAT-) and HCV seropositive viremic (HCV Ab+/NAT+) donors to HCV seronegative recipients on the liver transplant waitlist. Treatment and prophylaxis will be administered, using a transmission-triggered approach for the first scenario (HCV Ab+/NAT- donors, arm 1) and a prophylaxis approach for the later scenario (HCV Ab+/NAT+ donors, arm 2).

Key facts

Study ID
NCT03819322
Run by
Fernanda P Silveira, MD, MS
People needed
5
Starts
2019-08-15
Expected to finish
2025-03-17
Last updated by the study team
2026-04-30

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

Where it is running

Full record on ClinicalTrials.gov

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