A Meal-based Comparison of Protein Quality, Complementary Proteins and Muscle Anabolism

Completed · Not applicable

Conditions studied: Protein, Diet, Skeletal Muscle

In brief

To highlight the importance of protein quality rather than the total protein content of a meal, the investigators will demonstrate that unlike high quality proteins, a single meal containing 30 g of an incomplete protein source does not stimulate skeletal muscle protein synthesis. Secondly, the investigators will directly challenge a prevalent, but untested, assertion that has the potential to negatively impact health. The goal is to demonstrate that complementary plant-proteins (i.e., two or more incomplete protein sources) must be consumed at the same meal to stimulate protein synthesis.

Key facts

Study ID

NCT03816579

Run by

The University of Texas Medical Branch, Galveston

People needed

23

Starts

2019-03-26

Expected to finish

2021-01-21

Last updated by the study team

2021-04-29

Who can join

Age: 45 and older, up to 60. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• All races and ethnic backgrounds
• Men and women, age 45-60 years
• Generally healthy (see exclusion criteria)
• Able and willing to provide informed consent
• Ability to speak and read English (* the study procedures, e.g., muscle biopsy, duration of each acute study, e.g. overnight stay; and multiple dietary questionnaires require sound written and spoken English)

You may not qualify if…

• Sarcopenia (defined by: European Working Group on Sarcopenia in Older People, EWGSOP (44))
• Clinically significant heart disease (e.g. New York Heart Classification greater than grade II; ischemia)
• Peripheral vascular disease
• Pulmonary disease
• History of systemic or pulmonary embolus
• Uncontrolled blood pressure (systolic BP>170, diastolic BP>95 mmHg)
• Impaired renal function (creatinine >1.5 mg/dl)
• Anemia (hematocrit <33)
• Untreated thyroid disease (abnormal TSH)
• A recent history (<12 months) of GI bleed
• Diabetes mellitus or other untreated endocrine or metabolic disease
• Electrolyte abnormalities
• Any history of stroke, hypo- or hyper-coagulation disorders
• Recent (3 years) treated cancer other than basal cell carcinoma
• Systemic steroids, anabolic steroids, growth hormone or immunosuppressant use within 12 months
• Recent (6 months) adherence to a weight-loss or weight-gain diet
• Weight change of 5% or more in previous 6 months
• Body mass index >30 or excess body fat that compromises muscle biopsy collection
• Body mass index <20 or recent history (<12 month) of disordered eating
• Dietary preferences or practices that preclude the consumption of the study meals
• Acute infectious disease or chronic infection
• Alcohol or drug abuse
• Any other condition or event considered exclusionary by study physician
• Pregnancy

Where it is running

• Unversity of Texas Medical Branch — Galveston, Texas, United States

Full record on ClinicalTrials.gov

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