Efficacy and Tolerability Study of Two Dose Regimens of CTP-543 in Adults With Alopecia Areata

Completed · Phase 2 · Has a placebo group

Conditions studied: Alopecia Areata

In brief

This study will evaluate the efficacy and tolerability of once-daily versus twice-daily dosing of CTP-543, in adult patients with chronic, moderate to severe alopecia areata.

Key facts

Study ID

NCT03811912

Run by

Concert Pharmaceuticals

People needed

57

Starts

2019-03-21

Expected to finish

2019-11-21

Last updated by the study team

2022-12-09

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Definitive diagnosis of alopecia areata with a current episode lasting at least 6 months and not exceeding 10 years at the time of Screening. Total disease duration greater than 10 years is permitted.
• At least 50% scalp hair loss, as defined by a Severity of Alopecia Tool (SALT) score ≥50, at Screening and Baseline.
• Clinical lab results within the normal range

You may not qualify if…

• Active scalp inflammation, psoriasis, or seborrheic dermatitis requiring topical treatment to the scalp, significant trauma to the scalp, or untreated actinic keratosis on the scalp.
• Treatment with systemic immunosuppressive medications or biologics.
• Vaccination with herpes zoster vaccine or any live virus within 6 weeks of screening or during the study

Where it is running

• Investigative Site — Irvine, California, United States
• Investigative Site — San Francisco, California, United States
• Investigative Site — New Haven, Connecticut, United States
• Investigative Site — Boynton Beach, Florida, United States
• Investigative Site — Boston, Massachusetts, United States
• Investigative Site — Boston, Massachusetts, United States
• Investigative Site — Fridley, Minnesota, United States
• Investigative Site — Portsmouth, New Hampshire, United States
• Investigative Site — Winston-Salem, North Carolina, United States
• Investigative Site — Portland, Oregon, United States

Full record on ClinicalTrials.gov

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