Metabolomics Study on Postoperative Intensive Care Acquired Muscle Weakness
Recruiting now
Conditions studied: Metabolomics, Critical Care, Critical Illness, Critical Illness Myopathy, Critical Illness Polyneuropathy, Intensive Care (ICU) Myopathy, Muscle Weakness
In brief
In this mono-center pilot trial, surgical patients who are at high risk to be admitted to intensive care will be screened and asked for participation. We are going to take blood and muscle samples at respecified time points to do metabolic, histological and molecular testing. Aim of the study is to investigate (1) changes of the blood metabolome in patients with ICUAW (intensive care unit acquired weakness) and (2) identify metabolic components who are responsible for ICUAW or can be used as marker for ICUAW.
Key facts
- Study ID
- NCT03810768
- Run by
- Technical University of Munich
- People needed
- 20
- Starts
- 2022-09-02
- Expected to finish
- 2026-12-31
- Last updated by the study team
- 2026-03-03
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- invasive mechanically ventilated critically ill patient with expected intensive care unit stay > 3 days
- postoperative patient
- ≥ 18 years old
- American Society of Anesthesiology (ASA) classification ≥ III
You may not qualify if…
- moribund patient
- non-curative care (comfort care)
Where it is running
- Medical University of Vienna — Vienna, State of Vienna, Austria (enrolling)
- Klinikum rechts der Isar, School of Medicine, Technical University of Munich — Munich, Bavaria, Germany
- Charité - Universitätsmedizin Berlin — Berlin, State of Berlin, Germany
Full record on ClinicalTrials.gov
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