An Imaging Framework for Clinically Testing New Treatments to Prevent Post-traumatic OA

Completed · Not applicable

Conditions studied: Orthopedic Disorder, Trauma, Ankle Fractures, Post-traumatic Osteoarthritis

In brief

The immediate goal of the proposed research is to test the value of a new low-cost, low-dose standing CT system for efficient early detection of both joint degeneration and elevated contact stress. The standing CT scanner holds promise for detecting arthritic changes earlier than other imaging modalities because of the combination of its 3D nature and ability to image joints in a weight-bearing pose. A secondary goal of the proposed research is to enable predictive models for osteoarthritis risk based on measures of post treatment contact stress, both to inform treatment and so that new interventions can be tested in a manner incorporating risk stratification.

Key facts

Study ID

NCT03809520

Run by

J L Marsh

People needed

97

Starts

2017-02-01

Expected to finish

2022-03-31

Last updated by the study team

2026-04-24

Who can join

Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Individuals 18 to 70 years old Sustained an intra-articular fracture of the tibial plafond Indicated for operative treatment Present for treatment within 4 weeks of injury

You may not qualify if…

• Women who are pregnant or planning on becoming pregnant Individuals younger than 18 and older than 70

Where it is running

• University of Iowa Hospitals and Clinics — Iowa City, Iowa, United States

Full record on ClinicalTrials.gov

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