A Noninvasive Arterial Input Estimation Method for O-15 PET and Integrated PET/MR Scanning

Withdrawn before enrolling · Early Phase 1

Conditions studied: Validation of a New Noninvasive Method to Obtain the Arterial Input Function (AIF) Directly by PET Imaging

In brief

The overall aim of this project is to implement a non-invasive method of measuring quantitative regional cerebral blood flow (rCBF) on the UAB hybrid PET/MRI scanner to allow conducting such \[O-15\]water based scans with relative ease and safety in a large variety of important clinical and research applications. Participants will undergo imaging at baseline and after administration of a drug to increase cerebral blood flow to evaluate perfusion estimates during low and high flow states. The goal of this study is to generate data that will justify eliminating invasive arterial sampling in most \[O-15\]water-based PET protocols.

Key facts

Study ID

NCT03806751

Run by

University of Alabama at Birmingham

People needed

0

Starts

2025-02-01

Expected to finish

2027-02-01

Last updated by the study team

2024-03-01

Who can join

Age: 19 and older, up to 60. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Six participants aged 19-60 years of age, male and female, with no evidence of neurological disease, will be recruited from UAB and the surrounding community.

You may not qualify if…

• Participants will be excluded if there is any evidence or history of claustrophobia or the subject has metallic implants or devices that are normally exclusion factors for MRI.

Where it is running

• UAB Advanced Imaging Facility — Birmingham, Alabama, United States

Full record on ClinicalTrials.gov

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