Mechanisms of Pregnancy Vascular Adaptations

Recruiting now

Conditions studied: Pre-Eclampsia, Vascular Diseases

In brief

The investigators will collect omental tissue (research surgical excision) and placental tissue (standard of care clinical delivery) from both preeclamptic and non-preeclamptic women during their c-section and use these samples to study the blood vessels, specifically the expression/activation of the AT2R.

Key facts

Study ID

NCT03806283

Run by

University of Wisconsin, Madison

People needed

166

Starts

2018-11-20

Expected to finish

2027-04-01

Last updated by the study team

2026-01-20

Who can join

Age: 18 and older, up to 40. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Female
• Ages 18 to 40 years old
• Singleton gestation between 28 weeks, 0 days and 41 weeks, 0 days gestational age at the time of consent
• Undergoing caesarean section, either planned or otherwise with or without trial of labor

You may not qualify if…

• Treatment of severe hypertension by antihypertensive or use of magnesium sulfate after the patient is hospitalized for the diagnosis of preeclampsia.
• Any major fetal structural anomalies or aneuploidies
• Undergoing cesarean section for placental abruption or bleeding complications.
• Singleton gestation not within 36 weeks, 0 days and 41 weeks, 0 days gestational age at the time of enrollment (delivery)

Where it is running

• UnityPoint Health-Meriter Hospital — Madison, Wisconsin, United States (enrolling)

Full record on ClinicalTrials.gov

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