HDtDCS in Logopenic Variant PPA: Effects on Language and Neural Mechanisms

Completed · Not applicable · Has a placebo group

Conditions studied: Primary Progressive Aphasia

In brief

This study aims to evaluate the effectiveness of a therapy called High-Definition Transcranial Direct Current Stimulation (HD-tDCS) for the treatment of the language deficits experienced by people with a type of Primary Progressive Aphasia. This study uses a combination of brain imaging, language assessment, language training sessions, and HD-tDCS therapy as well as placebo therapy sessions.

Key facts

Study ID

NCT03805659

Run by

Medical College of Wisconsin

People needed

6

Starts

2020-02-24

Expected to finish

2022-05-18

Last updated by the study team

2024-06-11

Who can join

Age: 45 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosed with language variant Primary Progressive Aphasia (lvPPA) subtype, defined as either clinical lvPPA or imaging-supported lvPPA in accordance with the most recent diagnostic criteria (Mesulam., 2001; Gorno-Tempini et al., 2011).
• Fluent in English.
• 45 years of age or older.
• Structural brain MRI performed within 3 years prior to enrollment.

You may not qualify if…

• Severe cognitive, auditory or visual impairments that would preclude cognitive testing.
• Presence of major untreated or unstable psychiatric disease.
• A chronic medical condition that is not treated or is unstable.
• The presence of cardiac stimulators or pacemakers.
• Any metal implants in the skull
• Contraindications to MRI
• History of seizures
• History of dyslexia or other developmental learning disabilities.

Where it is running

• The Medical College of Wisconsin — Milwaukee, Wisconsin, United States

Full record on ClinicalTrials.gov

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