A Registry for Patients With Multifocal Ground Glass Opacities (GGOs)

Running, not enrolling

Conditions studied: Multiple Ground Glass Opacities (GGOs)

In brief

The purpose of this registry study is to actively monitor people with GGOs and collect information about them, so that investigators can learn more about these lesions and about the risk of developing lung cancer in study participants whose GGOs are being monitored in the active surveillance program.

Key facts

Study ID

NCT03802981

Run by

Memorial Sloan Kettering Cancer Center

People needed

338

Starts

2019-01-09

Expected to finish

2027-01-01

Last updated by the study team

2026-02-18

Who can join

Age: 19 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age greater than 18 years
• Have two or more GGOs on initial CT imaging
• GGOs must be measure ≤3.0 cm and ≥0.6 cm in the greatest dimension
• GGOs must be greater than half ground glass
• A biopsy is not necessary for inclusion in the trial. Biopsy of a GGO, even with a diagnosis of adenocarcinoma, does not necessarily preclude enrollment in this surveillance protocol. In other words, patients with a diagnosis of adenocarcinoma are still eligible, at the discretion of the clinician and/or investigator, if they meet the above criteria.

You may not qualify if…

• Patients who are actively undergoing lung cancer treatment or have a history of lung cancer, except for cases of completely resected pathologic stage IA nonsmall cell lung cancer (NSCLC). Patients with stage IA NSCLC and multiple GGOs can enroll in this active surveillance protocol after complete resection of the NSCLC and confirmation of stage on final pathologic assessment.
• The presence of any solid lesion ≥0.6 cm suspicious for malignancy.
• Patients who are actively undergoing treatment for other malignancies

Where it is running

• University of California San Diego — San Diego, California, United States
• Stanford University Medical Center (Data collection only) — Stanford, California, United States
• Hartford Healthcare — Hartford, Connecticut, United States
• Rush University Medical Center (Data collection only) — Chicago, Illinois, United States
• Massachusetts General Hospital Cancer Center — Boston, Massachusetts, United States
• Brigham and Women's Hospital — Boston, Massachusetts, United States
• University of Michigan — Ann Arbor, Michigan, United States
• Mayo Clinic — Rochester, Minnesota, United States
• George Washington University School of Medicine — St Louis, Missouri, United States
• Washington University School of Medicine — St Louis, Missouri, United States
• Memorial Sloan Kettering Basking Ridge — Basking Ridge, New Jersey, United States
• Memorial Sloan Kettering Monmouth — Middletown, New Jersey, United States
• Memorial Sloan Kettering Bergen — Montvale, New Jersey, United States
• Roswell Park Cancer Institute (Data Collection Only) — Buffalo, New York, United States
• Memorial Sloan Kettering Commack — Commack, New York, United States
• Memorial Sloan Kettering Westchester — Harrison, New York, United States
• Memorial Sloan Kettering Cancer Center — New York, New York, United States
• New York Presbyterian Hospital — New York, New York, United States
• Memorial Sloan Kettering Nassau — Uniondale, New York, United States
• Duke University Medical Center — Durham, North Carolina, United States
• Lehigh Valley Health Network — Allentown, Pennsylvania, United States
• University of Pennsylvania (Data Collection Only) — Philadelphia, Pennsylvania, United States
• Thomas Jefferson University Hospital — Philadelphia, Pennsylvania, United States
• Fox Chase Cancer Center — Philadelphia, Pennsylvania, United States
• Temple University — Philadelphia, Pennsylvania, United States

Full record on ClinicalTrials.gov

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