Study of PTG-300 in Non-Transfusion Dependent and Transfusion-Dependent Beta-Thalassemia Subjects With Chronic Anemia
Completed · Phase 2
Conditions studied: β-thalassemia, Ineffective Erythropoiesis, Chronic Anemia
In brief
This is a Phase 2 open-label, single-arm design study with dose escalation by subject cohort . The study is designed to monitor the PTG-300 safety profile, to obtain preliminary evidence of efficacy of PTG-300 for the treatment in β-thalassemia.
Key facts
- Study ID
- NCT03802201
- Run by
- Protagonist Therapeutics, Inc.
- People needed
- 63
- Starts
- 2018-12-19
- Expected to finish
- 2020-07-31
- Last updated by the study team
- 2021-07-16
Who can join
Age: 12 and older, up to 65. Sex: any. Healthy volunteers: not accepted.
Where it is running
- UCSF Benioff Children's Hospital — Oakland, California, United States
- Boston Children's Hospital — Boston, Massachusetts, United States
- Hospital of The University of Pennsylvania — Philadelphia, Pennsylvania, United States
- University General Hospital of Patras — Pátrai, Achaia, Greece
- Laiko General Hospital of Athens — Athens, Attica, Greece
- Athens General Hospital 'G Gennimatas' — Athens, Attica, Greece
- Hippokration Hospital — Thessaloniki, Greece
- Presidio Ospedaliero Antonio Perrino — Brindisi, Italy
- Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico — Milan, Italy
- AOU dell'Università degli Studi della Campania Luigi Vanvitelli — Naples, Italy
- Chronic Care Center — Beirut, Lebanon
- Hospital Ampang — Ampang, Malaysia
- Hospital Pulau Pinang — George Town, Malaysia
- Hospital Sultanah Aminah — Johor Bahru, Malaysia
- Queen Elizabeth Hospital — Kota Kinabalu, Malaysia
- Hospital Umum Sarawak — Kuching, Malaysia
- Chulalongkorn University — Bangkok, Thailand
- Siriraj Hospital Mahidol University — Bangkok, Thailand
- Maharaj Nakorn Chiang Mai Chiang Mai University — Chiang Mai, Thailand
- Khon Kaen University — Khon Kaen, Thailand
- Naresuan University — Phitsanulok, Thailand
- University Hospital Farhat Hached — Sousse, Tunisia
- Bone Marrow Transplant Center — Tunis, Tunisia
- Aziza Othmana Hospital — Tunis, Tunisia
- Principal Military Hospital — Tunis, Tunisia
Full record on ClinicalTrials.gov
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